Work

The Life Cycle of C-Myc: From Synthesis to Degradation

Year: 2004

Type: article

Abstract: The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.

Source: Cell Cycle

DOI: 10.4161/cc.3.9.1145

Author: Rosalie C. Sears

Institution: Oregon Health & Science University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Cancer Institute

Awards: Integration of Ras, Myc and E2F Signaling Pathways, Cellular Mechanisms Controlling Myc Protein Stability