Work

Palladium(II)-Catalyzed Dehydrogenative Alkenylation of Cyclic Enaminones via the Fujiwara–Moritani Reaction

Year: 2011

Type: article

Abstract: A new Pd(II)-catalyzed dehydrogenative alkenylation reaction involving two alkenes was developed. A variety of nonaromatic, cyclic enaminones were successfully coupled to primary and secondary alkenes yielding a series of unique 1,3-dienes. The generality of this transformation presents a useful strategy for directly cross-coupling alkenes and offers an attractive new approach to functionalize enaminones.

Source: Organic Letters

DOI: 10.1021/ol202677g

Authors: Yi-Yun Yu, Micah J. Niphakis, Gunda I. Georg

Institution: University of Minnesota

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G4594319155, Libraries for HTS: Privileged Structures in Sparsely Populated Chemical Space