Work

Redox-active radical scavenging nanomaterials

Year: 2010

Type: review

Abstract: Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging. Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage caused by increased reactive oxygen or nitrogen species, likely through their direct reaction with superoxide radical, since each of these materials has been shown to act as effective superoxide dismutase mimetics in vitro. This critical review discusses the chemistry of these nanomaterials and the context in which their radical scavenging activities have been studied in biological model systems. Current studies are focused on determining the uptake, metabolism, distribution, toxicity and fate of these nanomaterials in cell and animal model systems. Ultimately if shown to be safe, these nanomaterials have the potential to be used to reduce the damaging effects of radicals in biological systems (101 references).

Source: Chemical Society Reviews

DOI: 10.1039/b919677n

Authors: Ajay Karakoti, Sanjay Singh, Janet M. Dowding, Sudipta Seal, William T. Self

Institution: University of Central Florida

Language: English

Topic: Advanced Nanomaterials in Catalysis

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institute on Aging