How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission?
Year: 2007
Type: article
Abstract: OBJECTIVE: To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner. METHODS: Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV. RESULTS: Approximately 2760 (8.6%) of the estimated 32 000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections. CONCLUSIONS: Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed.
Source: AIDS
Author: Steven D Pinkerton
Institution: Medical College of Wisconsin
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2046513662