Work

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

Year: 2010

Type: review

Abstract: Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic beta-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate beta-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.

Source: Mediators of Inflammation

DOI: 10.1155/2010/453892

Authors: Hideaki Kaneto, Naoto Katakami, Munehide Matsuhisa, Taka-aki Matsuoka

Institution: The University of Osaka

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,040