Work

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

Year: 2012

Type: review

Abstract: Overwhelming are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functions of JNKs with recent discoveries on the role of JNKs in compensatory growth of neighboring cells and stem cells, which may provide new mechanistic understanding about the role of JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-11-1982

Author: Fei Chen

Institutions: Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Environmental Health Sciences