Work

Chrono-biology, Chrono-pharmacology, and Chrono-nutrition

Year: 2014

Type: review

Abstract: The circadian clock system in mammals drives many physiological processes including the daily rhythms of sleep-wake behavior, hormonal secretion, and metabolism. This system responds to daily environmental changes, such as the light-dark cycle, food intake, and drug administration. In this review, we focus on the central and peripheral circadian clock systems in response to drugs, food, and nutrition. We also discuss the adaptation and anticipation mechanisms of our body with regard to clock system regulation of various kinetic and dynamic pathways, including absorption, distribution, metabolism, and excretion of drugs and nutrients. "Chrono-pharmacology" and "chrono-nutrition" are likely to become important research fields in chrono-biological studies.

Source: Journal of Pharmacological Sciences

DOI: 10.1254/jphs.13r06cr

Authors: Yu Tahara, Shigenobu Shibata

Institution: Waseda University

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Fuji Foundation for Protein Research, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science