Work

Epidemiology of childhood acute myeloid leukemia

Year: 2013

Type: article

Abstract: Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.24464

Authors: Susan E. Puumala, Julie A. Ross, Richard Aplenc, Logan G. Spector

Institutions: University of South Dakota, Sanford Research, University of Minnesota, Masonic Cancer Center, Children's Hospital of Philadelphia

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute