Work

Human mesenchymal stem cells promote growth of osteosarcoma: Involvement of interleukin‐6 in the interaction between human mesenchymal stem cells and Saos‐2

Year: 2010

Type: article

Abstract: Our previous study showed that exogenous human mesenchymal stem cells (hMSCs) targeted established osteosarcoma and promoted its growth and pulmonary metastasis in vivo. As a follow-up, the present study aimed to investigate how hMSCs would interact with Saos-2 through autocrine/paracrine communication. The results showed that co-injection of hMSCs with Saos-2 into the proximal tibia of nude mice could promote tumor growth and progression. In vitro, the proliferation of Saos-2 and hMSCs was promoted by each other's conditioned medium, in which interleukin-6 (IL-6) played an important role. Osteogenic differentiation of hMSCs could be inhibited by conditioned medium of Saos-2, in which IL-6 was also involved. Furthermore, decreased IL-6 secretion by hMSCs during its osteogenesis and increased IL-6 secretion in response to conditioned medium of Saos-2 were observed. Based on these data, we suggest that there was a positive feedback loop of IL-6 in the interaction between hMSCs and Saos-2.

Source: Cancer Science

DOI: 10.1111/j.1349-7006.2010.01731.x

Authors: Zhen‐Yu Bian, Qi‐Ming Fan, Gang Li, Wen‐Ting Xu, Ting‐Ting Tang

Institutions: Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine, Chinese University of Hong Kong

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Shanghai Science and Technology Development Foundation, Shanghai Municipal Education Commission, Shanghai Key Laboratory of Orthopaedic Implants, Program for New Century Excellent Talents in University