Work

Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy- d -xylulose-5-phosphate reductoisomerase (Dxr) inhibitor

Year: 2014

Type: article

Abstract: We report here the enzymatic biosynthesis of FR-900098 analogues and establish an in vivo platform for the biosynthesis of an N-propionyl derivative FR-900098P. FR-900098P is found to be a significantly more potent inhibitor of Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase (PfDxr) than the parent compound, and thus a more promising antimalarial drug candidate.

Source: Chemical Communications

DOI: 10.1039/c4cc09181g

Authors: Ryan E. Cobb, Brian Bae, Zhi Li, Matthew A. DeSieno, Satish K. Nair, Huimin Zhao

Institutions: University of Illinois Urbana-Champaign, Carl R. Woese Institute for Genomic Biology

Language: English

Topic: Plant biochemistry and biosynthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences