Work

The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus

Year: 2005

Type: article

Abstract: This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis. Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus. LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.

Source: Journal of Bacteriology

DOI: 10.1128/jb.187.20.7161-7164.2005

Authors: S. O'Flaherty, A. Coffey, W. Meaney, G. F. Fitzgerald, R. P. Ross

Institutions: Teagasc - The Irish Agriculture and Food Development Authority, University College Cork, Munster Technological University, Cork Institute of Technology, APC Microbiome Institute

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Teagasc