Polymer models of the organization of chromosomes in the nucleus of cells
Year: 2015
Type: article
Abstract: Understanding the mechanisms that control the organization of chromosomes in the space of the nucleus of cells, and its contribution to gene regulation, is a key open issue in molecular biology. New technologies have shown that chromosomes have a complex 3D organization, which dynamically changes across organisms and cell types. To understand such complex behaviors, quantitative models from polymer physics have been developed, to find the principles of chromosome folding, their origin and function. Here, we provide a short review of recent progress in such an important research field where Physical and Life Sciences meet.
Source: Modern Physics Letters B
Authors: Andrea Maria Chiariello, Simona Bianco, Andrea Piccolo, Carlo Annunziatella, Mariano Barbieri, Ana Pombo, Mario Nicodemi
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2047024015