Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study
Year: 2012
Type: article
Study design: Observational Study
Abstract: Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p < 0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p < 0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p < 0.05). Adiponectin's contributions to arterial stiffness appear to be masked by other cardiovascular risk factors in persons with type 1 diabetes.
Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Cincinnati Medical Center, Wake Forest University Health Sciences, Wake Forest University, Colorado School of Public Health, University of Colorado Denver, University of Colorado Anschutz, University of Washington
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, National Institutes of Health, Centers for Disease Control and Prevention, U.S. Public Health Service, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Chronic Disease Prevention and Health Promotion, National Center for Advancing Translational Sciences
Awards: G1061576540, G1092462818, South Carolina Clinical & Translational Research Institute (SCTR), UCHSC Diabetes and Endocrinology Research Center, G206755211, Cincinnati Center for Clinical and Translational Sciences and Training, G249568976, G3146357332, G325765397, G3604266410, Institute of Translational Health Sciences, G3861154396, G4976965329, G561931883, General Clinical Research Center, General Clinical Research Center, G821379033, Cincinnati Center for Clinical and Translational Sciences and Training, G891215646, Research Training in Child Behavior and Nutrition, Colorado Nutrition Obesity Research Center, G951231213
OpenAlex ID: W2047098704