Work

MicroRNAs in Cancer: Small Molecules With a Huge Impact

Year: 2009

Type: review

Abstract: Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA expression signature is a hallmark of several diseases, including cancer. MicroRNA expression profiling has indeed provided evidence of the association of these tiny molecules with tumor development and progression. An increasing number of studies have then demonstrated that microRNAs can function as potential oncogenes or oncosuppressor genes, depending on the cellular context and on the target genes they regulate. Here we review our current knowledge about the involvement of microRNAs in cancer and their potential as diagnostic, prognostic, and therapeutic tools.

Source: Journal of Clinical Oncology

DOI: 10.1200/jco.2009.24.0317

Authors: Marilena V. Iorio, Carlo M. Croce

Institutions: Fondazione IRCCS Istituto Nazionale dei Tumori, The Ohio State University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Associazione Italiana per la Ricerca sul Cancro, National Cancer Institute