Year: 2009
Type: review
Abstract: BEGINNINGS IN EXOCRINE GLANDSStore-operated or capacitative calcium entry is a phenomenon whereby the depletion of intracellular Ca 2+ stores, generally from the endoplasmic reticulum, leads to the activation of plasma membrane Ca 2+ channels (1-3).The idea developed over a decade or so from studies of the relative roles and interactions of Ca 2+ release and Ca 2+ entry mechanisms in salivary and lacrimal gland cells.That many cell types utilize both intracellular release of Ca 2+ together with influx of Ca 2+ across the plasma membrane for the generation of cytoplasmic Ca 2+ signals have been appreciated for some time (4, 5).In salivary gland cells, it was shown that the Ca 2+ stores released by activation of autonomic receptors (muscarinic, α-adrenergic, substance P) required Ca 2+ influx through activated Ca 2+ channels for their replenishment (6).In the late 1970's and early 1980's, two key findings influenced thinking on how these two modes of signaling might interact.First, it became clear that the source of intracellular Ca 2+ for the release phase of responses was the endoplasmic reticulum (7, 8).Second, the signal for the release of Ca 2+ from the endoplasmic reticulum was shown to be the soluble product of phospholipase C activation, inositol 1,4,5-trisphosphate (IP3) (9, 10).
DOI: 10.2152/jmi.56.362
Authors: James W Putney, Gary S Bird
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Funder: National Institutes of Health
OpenAlex ID: W2047184710