Work

Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A

Year: 2004

Type: article

Abstract: Efficient and highly stereoselective syntheses of cryptophycin B and arenastatin A, potent cytotoxic agents, are described. An ester‐derived titanium enolate mediated syn‐aldol reaction was employed to generate the stereocenters C‐5 and C‐6. The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycins as well as members of its family. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.200300814

Authors: Arun K. Ghosh, Alexander Bischoff

Institution: University of Illinois Chicago

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS