Work

Long-circulating QD probes for in vivo tumor imaging

Year: 2004

Type: conference-paper

Abstract: Biocompatible semiconductor quantum dot (QD) probes with extended plasma circulating times have been developed for cancer imaging in living animals. The structural design involves encapsulating luminescent QDs with a triblock copolymer, and linking this amphiphilic polymer to multiple poly(ethylene glycol) (PEG) molecules. In vitro histology and in vivo imaging studies indicate that the QD probes can be delivered to tumor sites by enhanced permeation and retention. Using both systemic injection of long-circulating QD probes and subcutaneous injection of QD-tagged microbeads, we have achieved sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo.

Source: Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI: 10.1117/12.583226

Authors: Xiaohu Gao, Shuming Nie

Institutions: Georgia Institute of Technology, Emory University, Winship Cancer Institute

Language: English

Topic: Quantum Dots Synthesis And Properties

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Georgia Cancer Coalition, Emory University, National Institutes of Health