Work

Genetics of lipid disorders

Year: 2010

Type: article

Abstract: PURPOSE OF REVIEW: In this review, we will highlight recent advances in identifying genes and gene regions responsible for the variation in serum lipid levels. We will also consider the next directions for research based on these advances. RECENT FINDINGS: Large-scale genome-wide association studies have successfully screened common variants across the genome for association with serum lipids and have generated novel hypotheses about the causes of serum lipid variation. SUMMARY: Deep sequencing of genome-wide association signals promises to expand the catalogue of variants responsible for serum lipid variation and, with a full catalogue of variants, we may develop a panel of polymorphisms with clinical utility. In parallel, functional exploration of the genome-wide association signals should expand our knowledge of lipoprotein metabolism and generate targets for pharmacologic intervention.

Source: Current Opinion in Cardiology

DOI: 10.1097/hco.0b013e328338574d

Authors: James Pirruccello, Sekar Kathiresan

Institutions: Broad Institute, Johns Hopkins University, Massachusetts General Hospital

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute