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Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia

Year: 2011
Type: article
Abstract: Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways/molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field.
DOI: 10.1155/2012/308252
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: gold
Estimated APC paid: $860
Funders: CURE Childhood Cancer, Rally Foundation, Case Comprehensive Cancer Center, Case Western Reserve University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G2585869461, JAK/STAT Signaling in Hematopoietic Stem Cells, Metabolic regulation of hematopoietic stem cells, G5642861900, G5842928608, PTPMT1 Phosphatase and Hematopoietic Stem Cell Function, G9000182998
OpenAlex ID: W2047417247
FWCI: 1.509
Cites: 83
Cited by: 14
Related to: 10