Work

High Dose of Darunavir in Treatment-Experienced HIV-Infected Adolescent Results in Virologic Suppression and Improved CD4 Cell Count

Year: 2012

Type: article

Abstract: We describe an unintentional significant overdose of darunavir in a treatment-experienced adolescent with decreased darunavir susceptibility and prior treatment failure on darunavir therapy. Minimal toxicity and improved virologic suppression observed with an overdose have prompted consideration of the continued use of a higher than recommended dose. Pharmacokinetic and pharmacodynamic evaluations justified the individualized use of high-dose darunavir, which resulted in virologic suppression, improved CD4 cell count, and resolution of toxicity.

Source: Therapeutic Drug Monitoring

DOI: 10.1097/ftd.0b013e3182511efe

Authors: Natella Y. Rakhmanina, Michael N. Neely, Edmund V. Capparelli

Institutions: Children's National, George Washington University, University of California San Diego

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development