Work

The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons

Year: 2010

Type: article

Abstract: We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage produces parvalbumin(+) GABAergic neurons, ChAT(+) cholinergic neurons, and oligodendrocytes. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. Finally, our analysis provided evidence for a novel cellular component (Nkx2-1(-);Npas1(+)) of the globus pallidus.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.4228-09.2010

Authors: Pierre Flandin, Shioko Kimura, John L. R. Rubenstein

Institutions: University of California, San Francisco, National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, Weston Havens Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institute of Mental Health