Work

Change in Cardiovascular Risk Factors with Progression of Kidney Disease

Year: 2008

Type: article

Abstract: BACKGROUND: Prior studies evaluating the relationship of kidney disease with cardiovascular risk factors have been limited by their cross-sectional design. We evaluated the change in lipids, inflammatory and procoagulant biomarkers with decline in kidney function in a nested case-cohort study in the Cardiovascular Health Study, a community-based study of adults aged >65 years. METHODS: Individuals with an increase in serum creatinine >or=0.3 mg/dl (baseline to 3 years later, n = 207) were matched to controls of similar age, race, gender, diabetes and baseline serum creatinine, but whose change in creatinine was <0.3 mg/dl. Baseline and change in risk factors were analyzed with conditional logistic regression. RESULTS: Changes in C-reactive protein were similar. In contrast, cases had larger increases in fibrinogen (OR 1.38 per standard deviation, 95% confidence interval 1.08-1.76) and factor VIII [1.38 (1.10-1.72)] and larger decreases in HDL [OR 0.80 (0.64, 1.00)]. Change in interleukin-6 was greater in cases than controls, but this did not persist after multivariate adjustment. However, in linear regression, change in interleukin-6 was correlated with change in creatinine. CONCLUSION: Cardiovascular risk factors and kidney function may change concurrently. This could lead to an increased risk of cardiovascular disease as kidney function worsens.

Source: American Journal of Nephrology

DOI: 10.1159/000166598

Authors: Linda F. Fried, Ronit Katz, Mary Cushman, Mark Sarnak, Michael G. Shlipak, Lewis Kuller, Anne B. Newman

Institutions: University of Pittsburgh, VA Pittsburgh Healthcare System, University of Washington, University of Vermont, Tufts Medical Center, San Francisco VA Medical Center, University of California, San Francisco

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Veterans Affairs, Office of Research and Development, National Institutes of Health, Clinical Science Research and Development, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

Awards: G1023702118, G10717269, G1220223050, G125972088, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, CHS-ULTRASOUND READING, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, G1909643007, G2194386449, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, G277826483, G2800149121, G328935669, G34347772, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4012114008, G4048755144, G423252844, G4660668308, G4987078009, G5167412771, CHS Events Follow-up Study, G6226795708, CHS-Transition Phase, Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults, G687544517, G7286144250, CHS RETINAL READING CENTER, G764651519, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G766700449, G777822606, G783845518, G7999488110, G806768229, G8593276544, G859984287, G905887895, G936067872, G960597250

OpenAlex ID: W2047553232

FWCI: 1.438

Cites: 35

Cited by: 12

Related to: 10