Work

On the Prevention and Analysis of Missing Data in Randomized Clinical Trials: The State of the Art

Year: 2012

Type: article

Abstract: We summarize and elaborate on the recently published National Research Council report entitled "The Prevention and Treatment of Missing Data in Clinical Trials." We tailor our discussion to orthopaedic trials. In particular, we discuss the intent-to-treat principle, review study design and prevention ideas to minimize missing data, and present state-of-the-art sensitivity analysis methods for analyzing and reporting the results of studies with missing data.

Source: Journal of Bone and Joint Surgery

DOI: 10.2106/jbjs.l.00273

Authors: Daniel O. Scharfstein, Joseph Hogan, Amir Herman

Institutions: Johns Hopkins University, Brown University, Sheba Medical Center

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Alcohol Abuse and Alcoholism