Work

Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain

Year: 1997

Type: article

Abstract: Acute phase serum amyloid A (A-apoSAA), but not constitutive apoSAA (C-apoSAA), was identified by Western blotting experiments in brain protein extracts from eight of nine patients with Alzheimer's disease (AD), one with a brain tumor and one with multiple sclerosis. A-apoSAA was not detected in six subjects with Pick's or Lewy Body disease or three other non-AD brain specimens. Apolipoprotein A-I and albumin were not found in any of the brain protein extracts. A-apoSAA mRNA was detected in AD brain by reverse transcription-polymerase chain reaction (RT-PCR). These data suggest that apoSAA is locally produced in AD brain and that investigation of the neuroinflammatory effects of this injury specific apolipoprotein is warranted.

Source: Neuroscience Letters

DOI: 10.1016/s0304-3940(97)00196-1

Authors: Jun-shan Liang, Jacob A Sloane, John M Wells, Carmela R Abraham, Richard E Fine, Jean D Sipe

Institutions: Boston University, Edith Nourse Rogers Memorial Veterans Hospital

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430