Work

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents

Year: 2015

Type: article

Abstract: -acetyl-D-glucosamine portions in their structures. Their stereospecific chemical synthesis, which involves a substrate-dependent stereospecific glycosylation step, and their biological activity in reducing lactate production and proliferation in cancer cells are reported. Interestingly, the α-D-mannose conjugate displayed the best properties in the cellular assays, demonstrating an efficient antiglycolytic and antiproliferative activity in cancer cells.

Source: RSC Advances

DOI: 10.1039/c5ra00946d

Authors: Valeria Di Bussolo, Emilia C. Calvaresi, Carlotta Granchi, Linda Del Bino, Ileana Frau, Maria Chiara Dasso Lang, Tiziano Tuccinardi, Marco Macchia, Adriano Martinelli, Paul J. Hergenrother, Filippo Minutolo

Institutions: University of Pisa, University of Illinois Urbana-Champaign, University of Illinois System

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Design, Synthesis, and Evaluation of Lactate Dehydrogenase Inhibitors, Biological characterization of a novel class of lactate dehydrogenase A (LDH-A) i

OpenAlex ID: W2047982230

FWCI: 1.675

Cites: 25

Cited by: 25

Related to: 10