Work

Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation

Year: 2008

Type: article

Abstract: General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.

Source: Organic Letters

DOI: 10.1021/ol702821j

Authors: Smaranda C. Marinescu, Toyoki Nishimata, Justin T. Mohr, Brian M. Stoltz

Institution: California Institute of Technology

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: The Synthesis of Bioactive Polycyclic Natural Products