Work

Templated Construction of a Zn-Selective Protein Dimerization Motif

Year: 2011

Type: article

Abstract: Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization.

Source: Inorganic Chemistry

DOI: 10.1021/ic200746m

Authors: Eric N. Salgado, Jeffrey D. Brodin, Magnus M. To, F. Akif Tezcan

Institution: University of California San Diego

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

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