Year: 2003
Type: letter
Abstract: Thyroid DiseaseT ype 1 diabetes is associated with other autoimmune diseases.Many diabetes centers routinely screen patients with type 1 diabetes for autoimmune thyroid disease (ATD).The presence of two autoimmune diseases raises the possibility of polyendocrine autoimmune disease.The association of autoimmune adrenal insufficiency, or Addison's disease, with type 1 diabetes is described in case reports dating back more than a century (1,2).Studies have i l l u s t r a t e d s h a r e d H L A a l l e l e s (DQA1*0501, for example) among patients with type 1 diabetes, ATD, and Addison's disease (3,4).Pancreatic islet cell antibodies have been detected in 6.2% of patients with Addison's disease ( 5).Yet, it is unclear whether patients with type 1 diabetes should be routinely screened for Addison's disease.Our study's objective was to determine whether routine screening for Addison's disease is warranted in children with both type 1 diabetes and ATD.Children were diagnosed with thyroid disease if they had thyroid peroxidase antibodies (TPOs Ͼ50 Ku/l) and/or were receiving thyroid hormone replacement for primary hypothyroidism.A population of children with type 1 diabetes but without thyroid disease was also screened.The study population consisted of 114 children with type 1 diabetes, 35 (25 girls and 10 boys) with thyroid disease (28 on L- thyroxine) and 79 (42 girls and 37 boys) without thyroid disease (normal thyroidstimulating hormone and TPO Ͻ50 Ku/ l).Adrenal antibodies were measured by standard immunofluorescent technique (Nova Century Scientific-Immco antiadrenal slides), and TPOs were measured by an automated electrochemiluminescence immunoassay (Roche Elecsys 2010).
Source: Diabetes Care
Authors: Thomas Hardy, Alan Breier
Institution: Eli Lilly (United States)
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2048130835