The Non-Muscle Myosin Heavy Chain 9 Gene (MYH9) Is Not Associated with Lupus Nephritis in African Americans
Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: African Americans (AA) disproportionately develop lupus nephritis (LN) relative to European Americans and familial clustering supports causative genes. Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN. METHODS: Seven MYH9 single nucleotide polymorphisms (SNPs) and the E1 risk haplotype were tested for association with LN in three cohorts of AA. RESULTS: A preliminary analysis revealed that the MYH9 E1 risk haplotype was associated with ESRD in 25 cases with presumed systemic lupus erythematosus (SLE)-associated ESRD, compared to 735 non-SLE controls (odds ratio 3.1; p = 0.010 recessive). Replication analyses were performed in 583 AA with SLE in the PROFILE cohort (318 with LN; 265 with SLE but without nephropathy) and 60 AA from the NIH (39 with LN; 21 with SLE but without nephropathy). Analysis of the NIH and larger PROFILE cohorts, as well as a combined analysis, did not support this association. CONCLUSIONS: These results suggest that AA with ESRD and coincident SLE who were recruited from dialysis clinics more likely have kidney diseases in the MYH9-associated spectrum of focal segmental glomerulosclerosis. PROFILE and NIH participants, recruited from rheumatology practices, demonstrate that MYH9 does not contribute substantially to the development of LN in AA.
Source: American Journal of Nephrology
DOI: 10.1159/000314688
Authors: Barry I. Freedman, Jeffrey C. Edberg, Mary E. Comeau, Mariana Murea, Donald W. Bowden, Jasmin Divers, Graciela S. Alarcón, Elizabeth E. Brown, Gerald McGwin, Jr., Jeffrey B. Kopp, Cheryl A. Winkler, George W. Nelson, Gabor Illei, Michelle Petri, Rosalind Ramsey-Goldman, John D. Reveille, Luis M. Vilá, Carl D. Langefeld, Robert P. Kimberly, for the PROFILE Study Group
Institutions: Wake Forest University Health Sciences, Wake Forest University, University of Alabama at Birmingham, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, Science Applications International Corporation (United States), National Institute of Dental and Craniofacial Research, Johns Hopkins University, Northwestern University, The University of Texas Health Science Center at Houston, University of Puerto Rico, Medical Sciences Campus
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1356092923, G1653542590, DCTD Computer Support, G1799052500, G3277247684, G3503792436, G386607036, Mapping Genes for NIDDM Nephropathy in African Americans, G4585269469, G5211619743, An Integrative Genomic Approach to APOL1-Associated Nephropathy., G5888954722, A National Consortium to Explore the Genotypic Basis for ESRD in Lupus, Natural History of MYH9-Associated Nephropathy, Program Project in the Genetics of SLE, G722041973, Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)
OpenAlex ID: W2048172460