Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis
Year: 2008
Type: article
Abstract: A novel fiber-optic-based method for simultaneous time- and wavelength-resolved fluorescence spectroscopy for the rapid diagnosis of diseased tissue is demonstrated. By combining multiple bandpass and dichroic filters (405/40, 460/50, and 550/50) with different lengths of optical fiber (1, 10, and 19 m) acting as an optical delay this system enables the near real-time acquisition and characterization of time-resolved fluorescence spectra using a single detector and excitation input. The recording of multiple fluorescence response pulses at selected wavelengths can be completed in hundreds of nanoseconds, which provides the capability of a real-time characterization of biological systems.
Source: Optics Letters
DOI: 10.1364/ol.33.000630
Authors: Yinghua Sun, Rui Liu, Daniel S. Elson, Christopher W. Hollars, Javier A. Jo, Jesung Park, Yang Sun, Laura Marcu
Institutions: University of California, Davis, Imperial College London
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2048208399