Work

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Year: 2009

Type: article

Source: Journal of Molecular Biology

DOI: 10.1016/j.jmb.2009.02.045

Authors: Kathleen M. Frey, Jieying Liu, Michael N. Lombardo, David B. Bolstad, Dennis L. Wright, Amy C. Anderson

Institution: University of Connecticut

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering

Awards: G1970286180, Targeting Bacillus DHFR: Structural Studies and Synthesis of Inhibitors, Targeting DHFR to Design Antimicrobial Agents, G6246614152, Case Center for Synchrotron Bioscience, Potent and selective DHFR inhibitors for treating Cryptosporidiosis

OpenAlex ID: W2048236910

FWCI: 4.127

Cites: 23

Cited by: 55

Related to: 10