Work

Remotely activated, vibrational magnetoelastic array system for controlling cell adhesion

Year: 2013

Type: article

Abstract: A new system was designed to selectively control cellular adhesion to medical implants. The system is based on magnetoelastic (ME) materials that can be remotely set to generate mechanical vibrations at submicron levels with predetermined amplitude and frequency. Previous studies have demonstrated the capacity of these vibrations to control cellular adhesion at a substrate surface. In this work, an ME film with two conjoined strips was developed to investigate the potential of this system to provide region specific control of cellular adhesion. In vitro cell culture experiments performed with L929 fibroblasts indicate that cellular adhesion can be increased or decreased at different regions of the film by changing the frequency of the magnetic field.

Source: Journal of Biomedical Science and Engineering

DOI: 10.4236/jbise.2013.64060

Authors: Steven Trierweiler, Hallie Holmes, Brandon Pereles, Rupak Rajachar, Keat Ghee Ong

Institution: Michigan Technological University

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Institutes of Health