Work

Rapid immune reconstitution and complete donor chimerism after non-myeloablative allogeneic peripheral blood stem cell transplantation (NMSCT) in pediatric patients (PTS) with malignancy

Year: 2006

Type: article

Abstract: Background: Experience with NMSCT for pediatric cancer is limited. Compared to adults, children and adolescents have less immune depletion and improved reconstitution after chemotherapy, which might increase the risk of graft rejection or mixed chimerism. On the other hand, preserved host thymic function might enhance donor-derived immune recovery. We postulated that pre-transplant immune depletion followed by T cell replete NMSCT would facilitate donor engraftment and enhance post-transplant immune reconstitution.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.251