Phenotype Refinement Strengthens the Association of AHR and CYP1A1 Genotype with Caffeine Consumption
Year: 2014
Type: article
Abstract: Two genetic loci, one in the cytochrome P450 1A1 (CYP1A1) and 1A2 (CYP1A2) gene region (rs2472297) and one near the aryl-hydrocarbon receptor (AHR) gene (rs6968865), have been associated with habitual caffeine consumption. We sought to establish whether a more refined and comprehensive assessment of caffeine consumption would provide stronger evidence of association, and whether a combined allelic score comprising these two variants would further strengthen the association. We used data from between 4,460 and 7,520 women in the Avon Longitudinal Study of Parents and Children, a longitudinal birth cohort based in the United Kingdom. Self-report data on coffee, tea and cola consumption (including consumption of decaffeinated drinks) were available at multiple time points. Both genotypes were individually associated with total caffeine consumption, and with coffee and tea consumption. There was no association with cola consumption, possibly due to low levels of consumption in this sample. There was also no association with measures of decaffeinated drink consumption, indicating that the observed association is most likely mediated via caffeine. The association was strengthened when a combined allelic score was used, accounting for up to 1.28% of phenotypic variance. This was not associated with potential confounders of observational association. A combined allelic score accounts for sufficient phenotypic variance in caffeine consumption that this may be useful in Mendelian randomization studies. Future studies may therefore be able to use this combined allelic score to explore causal effects of habitual caffeine consumption on health outcomes.
Source: PLoS ONE
Institutions: University of Bristol, MRC Integrative Epidemiology Unit
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: Wellcome Trust, United Kingdom Clinical Research Collaboration, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, University of Bristol, National Institutes of Health, Medical Research Council, Economic and Social Research Council, National Center for Advancing Translational Sciences
Awards: G1462096072, G1475706641, G149876332, G235045266, G2461617102, Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression, G301055538, DECIPHer: Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement, G3905579758, G4182683118, G4301517698, The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019., The Avon Longitudinal Study of Parents and Children: An international resource for population
genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019, G5001017760, Center for Clinical and Translational Science and Training, The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2013., G6119919417, G6737906592, G8728195065
OpenAlex ID: W2048610563