Work

Nerve dependence in tissue, organ, and appendage regeneration

Year: 2012

Type: review

Abstract: Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.

Source: Trends in Neurosciences

DOI: 10.1016/j.tins.2012.08.003

Authors: Anoop Kumar, Jeremy P. Brockes

Institutions: Institute of Structural and Molecular Biology, University College London

Language: English

Topic: Nerve injury and regeneration

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funder: Medical Research Council