Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
Year: 1989
Type: article
Study design: Observational Study
Abstract: Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.
Authors: L M Sollid, G Markussen, J Ek, H Gjerde, F Vartdal, E Thorsby
Institution: University of Oslo
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2048796508