P3‐248: Post‐operative cognitive changes are strikingly similar to that seen in Alzheimer's disease
Year: 2010
Type: article
Study design: Observational Study
Abstract: Cognitive decline after coronary artery bypass grafting is recognized and well-documented. The purpose of this study was to evaluate whether the level of cognitive biomarkers after heart surgery correlate with the development of cognitive dysfunction. Concentrations of β-amyloid peptide, tau and S100β in the cerebrospinal fluid were assessed before and after coronary artery bypass grafting, utilizing immuno-assays. A drastic rise in the level of S100β was observed 1 week after the surgery, the mark of a severe cerebral injury. The level of β-amyloid peptide significantly decreased, whereas the concentration of tau markedly increased 6 months postoperatively. These findings clearly demonstrate that changes in biomarkers after heart surgery are similar to that seen in Alzheimer's disease, confirming the cognitive decline after cardiac interventions at the molecular level.
Source: Alzheimer s & Dementia
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2049054532