Work

Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury

Year: 1993

Type: article

Abstract: We evaluated the therapeutic effects of two noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, MgCl2 and ketamine, both individually and together, on cognitive dysfunction observed following parasagittal fluid-percussion (FP) brain injury in the rat. Using a modified Morris water maze technique, we found significant attenuation of post-traumatic memory dysfunction in animals treated with either MgCl2 (125 mumol) or ketamine (4 mg/kg) (P < 0.005). Combined MgCl2 and ketamine treatment also preserved memory function (P < 0.005), with no apparent additive effect.

Source: Neuroscience Letters

DOI: 10.1016/0304-3940(93)90739-8

Authors: Douglas H. Smith, Koichi Okiyama, Thomas A. Gennarelli, Tracy K. McIntosh

Institution: University of Pennsylvania

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430