A membrane-associated RNA of cytoplasmic origin in HeLa cells.
Year: 1967
Type: article
Abstract: The genetic evidence of the existence in yeast [1] and molds [2] of cytoplasmic determinants controlling the structure and function of mitochondria and the demonstration that mitochondria from all organisms contain DNA [3-7] have indicated that transcription and translation processes dependent on cytoplasmic genes occur in eukaryotic cells. More recent observations in Neurospora have suggested that a cytoplasmic, presumably mitochondrial, genetic determinant controls the structural proteins of different membrane systems (mitochondria, microsomes, nuclear membrane) [8, 9]; these structural proteins, from their amino acid composition, fingerprinting pattern, and immunological behavior, appear to be identical or to have a common component. [8, 9] These findings suggest that cytoplasmic genes may have a wider role in the cell than hitherto suspected and may direct a considerable fraction of mRNA and protein synthesis.
Authors: B Attardi, G Attardi
Institution: California Institute of Technology
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2049317535