EEG Delta, Positron Emission Tomography, and Memory Deficit in Alzheimer’s Disease
Year: 2008
Type: article
Study design: Observational Study
Abstract: Quantitative scalp EEG from 32 channels and the cerebral glucose metabolic rate from the 32 underlying cortical positions as assessed by positron emission tomography (PET) with 18F-2-deoxyglucose (FDG) were obtained on 36 patients with mild to moderate senile dementia of the Alzheimer type and 17 age- and sex-matched normal control subjects. Subjects performed a verbal memory task during uptake of FDG. There were significant correlations between both delta amplitude and metabolic rate and memory performance during FDG uptake. Patients with Alzheimer's disease had significantly greater left temporal delta amplitude and lower glucose metabolic rates. Both EEG delta in microvolts and metabolic rate had similar diagnostic sensitivity, but PET had fewer false positives among normals. The left amygdala had the highest sensitivity and percent correct diagnosis of any brain area. Temporal lobe EEG delta activity showed higher correlations with hippocampal metabolic rate than metabolic rate directly under the electrode.
Source: Neuropsychobiology
DOI: 10.1159/000119189
Authors: Dirceu C. Valladares-Neto, Monte S. Buchsbaum, James Evans, Dorothy Nguyen, Patricia Nguyen, Benjamin V. Siegel, Jill Stanley, Arnold Starr, Steven Guich, Daniel Rice
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2049319416