Work

A Markov model approach to predicting regional tumor spread in the lymphatic system of the head and neck.

Year: 2006

Type: article

Abstract: Radiation planning for cancer therapy is becoming more and more dependent on the prediction of microscopic tumor spread to regional lymph nodes for its success. It is known that microscopic spread tends to follow established lymphatic drainage pathways in the head and neck based on the location of the primary tumor. In this paper,we propose a novel model for the prediction of regional lymphatic involvement of head and neck squamous cell carcinoma based on primary tumor location and T-stage. The proposed model operates from first anatomical principles and basic stochastic techniques, and is validated against surgical data.

Source: Europe PMC (PubMed Central)

Authors: Noah Benson, Mark Whipple, Ira J Kalet

Institution: University of Washington

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: U.S. National Library of Medicine

Award: University of Washington Biomedical Informatics and Data Science Research Training Program