Issues in solid-organ transplantation in children: translational research from bench to bedside
Year: 2014
Type: review
Abstract: In this review, we identify important challenges facing physicians responsible for renal and cardiac transplantation in children based on a review of the contemporary medical literature. Regarding pediatric renal transplantation, we discuss the challenge of antibody-mediated rejection, focusing on both acute and chronic antibody-mediated rejection. We review new diagnostic approaches to antibody-mediated rejection, such as panel-reactive antibodies, donor-specific cross-matching, antibody assays, risk assessment and diagnosis of antibody-mediated rejection, the pathology of antibody-mediated rejection, the issue of ABO incompatibility in renal transplantation, new therapies for antibody-mediated rejection, inhibiting of residual antibodies, the suppression or depletion of B-cells, genetic approaches to treating acute antibody-mediated rejection, and identifying future translational research directions in kidney transplantation in children. Regarding pediatric cardiac transplantation, we discuss the mechanisms of cardiac transplant rejection, including the role of endomyocardial biopsy in detecting graft rejection and the role of biomarkers in detecting cardiac graft rejection, including biomarkers of inflammation, cardiomyocyte injury, or stress. We review cardiac allograft vasculopathy. We also address the role of genetic analyses, including genome-wide association studies, gene expression profiling using entities such as AlloMap®, and adenosine triphosphate release as a measure of immune function using the Cylex® ImmuKnow™ cell function assay. Finally, we identify future translational research directions in heart transplantation in children.
Source: Clinics
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,700
Funders: Lance Armstrong Foundation, Diabetes Research Institute Foundation, Armstrong Foundation, Nephcure Foundation, Children's Cardiomyopathy Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1150073368, G1444413186, G156320786, G1579334765, Pediatric Cardiomyopathy Registry, Training Program in Cardiovascular Signaling, Genetic Mechanisms of Anthracycline Cardiotoxicity in Pediatric Cancer Survivors, Atherosclerotic Risk and Response to Exercise Intervention in HIV+ Children, G268392486, G2751068800, Cardiovascular Status of HAART-Exposed Infants/Children, G2877901988, Role of nephrin in pancreatic beta cell function, G3316764012, G3365471892, G402565392, Pediatric Cardiomyopathy Specimen Repository, G4576131931, Pediatric HIV/AIDS Cohort Study (PHACS) Coordinating Center (CC) (U01), Therapeutic Index of Acute Lymphoblastic Leukemia, G4877564748, HAART Associated Cardiotoxicity in HIV-Infected Children, Primary Cardiomyopathies in Children: Research Directions & Strategies, G5560106399, G5917784638, Women and Infants Transmission Study IV, Baseline Predictors of Outcomes of Pediatric Dilated Cardiomyopathy, Pediatric HIV/AIDS Cohort Study (PHACS): Data and Operations Center (DOC)., FELLOWSHIP IN CLINICAL RESEARCH, G7717680024, G7826780446, G7947996496, G8402651462, G8418612192, Novel Targets of Rituximab in FSGS, G9000029296, G9000036457, G9000044172, G9000097852, G9000121309, G9000251789, G9000322694
OpenAlex ID: W2049385428