Immunotherapy of Viral Infections Other than HIV
Year: 2002
Type: book-chapter
Abstract: Our understanding of the immune system’s role in eliminating acute viral infections, in suppressing latent viral pathogens, and in the pathogenesis of chronic viral infection has grown in the past decade, leading to strategies for modulating the immune response as a potential adjunct to existing antiviral therapy when it exists or as stand-alone therapy in infections for which effective antiviral agents do not yet exist. Administration of antibody, both to prevent acute infection (as in the case of respiratory syncytial virus [RSV]) and to ameliorate chronic infection (as in the case of hepatitis B) is but one example of specifically targeted immunobased therapy. Administration of cytokines, such as interleukin-12 (IL-12), is a more innovative approach to modulating immune responses in general and suppressing chronic infection. The adoptive transfer of pathogen-specific cytotoxic T-cells has been effective in prevention of Epstein-Barr virus (EBV)-related disease post transplant.
Source: Humana Press eBooks
Authors: Michelle Onorato, Richard B. Pollard
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W204958215