Year: 2011
Type: article
Abstract: Material and methods For a large-scale dataset of over 200,000 SNPs from about 200 individuals together with several phenotypes, published by Atwell et al. [1], we develop efficient methods to find pairs of SNPs which are strongly associated with the phenotype. As an exhaustive search of all possible combinations of interacting SNPs is often unfeasible, even when only considering pairs of interacting SNPs, the challenge is to find methods which avoid an exhaustive search but can still guarantee to find the causal pair. We propose two distinct approaches to efficiently determine the t top-scoring pairs of SNPs.
Source: BMC Bioinformatics
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,990
OpenAlex ID: W2049660538