Work

Design and Synthesis of (13S)‐Methyl‐Substituted Arachidonic Acid Analogues: Templates for Novel Endocannabinoids

Year: 2010

Type: article

Abstract: Two novel methyl-substituted arachidonic acid derivatives were prepared in an enantioselective manner from commercially available chiral building blocks, and were found to be excellent templates for the development of (13S)-methyl-substituted anandamide analogues. One of the compounds synthesized, namely, (13S,5Z,8Z,11Z,14Z)-13-methyl-eicosa-5,8,11,14-tetraenoic acid N-(2-hydroxyethyl)amide, is an endocannabinoid analogue with remarkably high affinity for the CB1 cannabinoid receptor.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.200902880

Authors: Demetris P. Papahatjis, Victoria R. Nahmias, Spyros P. Nikas, Marion Schimpgen, Alexandros Makriyannis

Institutions: National Hellenic Research Foundation, Northeastern University

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Drug Abuse