Work

Effect of CAL-101, a PI3Kδ inhibitor, on ribosomal rna synthesis and cell proliferation in acute myeloid leukemia cells

Year: 2014

Type: article

Abstract: Acute myeloid leukemia (AML) accounts for ∼ 80% of all adult leukemias and the majority of patients will relapse and die from this disease, indicating an unmet need for new therapies. 1 , 2 The PI3K/Akt pathway, which is frequently constitutively activated in leukemic blasts from AML patients,coordinates the synthesis of ribosomal proteins and rRNA that is required for cellular proliferation. 3 , 4 , 5 The overall survival of AML patients whose blasts demonstrated Akt activation was significantly shorter than that of patients without Akt activation, suggesting that this pathway could represent an important therapeutic target. 3 , 6

Source: Blood Cancer Journal

DOI: 10.1038/bcj.2014.49

Authors: L X T Nguyen, A Sesay, B S Mitchell

Institutions: Stanford Medicine, Stanford Cancer Institute, Stanford University

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,290