Function of the MHC.
Year: 1958
Type: article
Abstract: The major histocompatibility complex (MHC) was discovered originally as a genetic locus controlling rapid rejection of tissue grafts. Subsequently, study of antibody responses in vivo and T-cell responses in vitro to MHC antigens identified the presence of a number of closely linked loci within the MHC. Immune response (Ir) genes also mapped to the MHC. The discovery of MHC restriction and the molecular identification of MHC genes and their products has led to a unified theory of the principal function of MHC molecules to act as guidance molecules for T-cell responses. Additional functions are suggested by their association with cell surface receptors.
Source: PubMed Central
Authors: P B MEDAWAR, M F WOODRUFF
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W20501082