Work

The contribution of CCR1 expression on donor leukocytes to the development of experimental idiopathic pneumonia syndrome

Year: 2005

Type: article

Abstract: Idiopathic Pneumonia Syndrome (IPS) is a severe complication of allogeneic (allo) bone marrow transplantation (BMT). IPS is characterized by cellular infiltration into the lung that results in altered pulmonary function and death in the majority of patients. Leukocyte recruitment during the development of IPS is mediated by chemokines and their receptors. Specifically, we have recently shown an important role for CCL5 (RANTES) in the development of lung injury following BMT. Receptors for CCL5 include both CCR5 and CCR1.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2004.12.137