Work

Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

Year: 2008

Type: article

Abstract: The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja710321g

Authors: Mary-Catherine Bowman, T. Eric Ballard, Christopher J. Ackerson, Daniel L. Feldheim, David M. Margolis, Christian Melander

Institutions: University of North Carolina at Chapel Hill, North Carolina State University, University of Colorado Boulder

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Eye Institute, National Institute of Allergy and Infectious Diseases