Work

Mitochondrial respiratory chain inhibitors induce apoptosis

Year: 1994

Type: article

Abstract: In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and the highly specific mitochondrial ATP-synthase inhibitor oligomycin are shown to induce an apoptotic suicide response in cultured human lymphoblastoid and other mammalian cells within 12-18 h. The mitochondrial inhibitors do not induce apoptosis in cells depleted of mitochondrial DNA and thus lacking an intact mitochondrial respiratory chain. Apoptosis induced by respiratory chain inhibitors is not inhibited by the presence of Bcl-2. We discuss the possible role of mitochondrial induced apoptosis in the ageing process and age-associated diseases.

Source: FEBS Letters

DOI: 10.1016/0014-5793(94)80380-3

Authors: Ernst J. Wolvetang, Karina L. Johnson, Kenia Krauer, Steve J. Ralph, Anthony W. Linnane

Institution: Monash University

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2050365720

FWCI: 8.811

Cites: 22

Cited by: 401

Related to: 8